Optical Manipulation and Laser-Based Microscopy

Maria Dienerowitz is Professor of Laser Technology at the Ernst-Abbe-Hochschule Jena (EAH), specializing in optical manipulation and instrumentation. At the Deutsches Optisches Museum, she leads the team for the development of interactive exhibits and the integration of physical concepts into the exhibition. 

She studied physics at the University of Karlsruhe (TH) and the University of Central Florida, completing her degree with distinction in 2005. Her doctoral research at the University of St Andrews focused on optical tweezers and plasmonic nanoparticles. Subsequently, she conducted postdoctoral research at the University of Glasgow, working on piconewton force measurements and holographic beam shaping. Before joining EAH Jena in October 2022, she expanded her research in single-molecule microscopy at the University Hospital in Jena. 

Research Areas

The group’s research encompasses optical and single-molecule trapping as well as the development of compact optical instruments that enable the direct investigation of bacteria and single molecules in biological laboratories. In parallel, the group designs laser metrology systems for cultural heritage applications, such as the contact-free characterisation of historical spectacle lenses for the Deutsches Optisches Museum.

Main research topics include:

• Optical manipulation of nanoparticles and biomolecules using optical tweezers and holographic beam shaping.
• Single-molecule trapping and fluorescence techniques such as Förster Resonance Energy Transfer (FRET) to study molecular dynamics.
• Development of integrated optical systems for biomedical diagnostics, including microfluidics lab-on-a-chip devices.
• Development of didactic laboratory experiments in optics and concepts for interactive science communication in museum exhibitions.

Prof. Dienerowitz is currently leading several research projects that integrate optics and biomedicine. One of her projects, BioLOC aims to develop a lab-on-a-chip system for the optical characterization of molecular dynamics. This system combines microfluidics with light-sheet microscopy to analyze freely moving single molecules, enhancing sensitivity and minimizing interference.  Another project, OPTO, involves measuring historical spectacle lenses in collaboration with the Deutsches Optisches Museum, focusing on the optical properties of antique eyewear.  Additionally, she co-leads the TOOLS initiative, a DFG-funded interdisciplinary project that develops tailored optical systems for biomedical applications, such as detecting bio-nanoparticles and improving endoscopic diagnostics.