Heme and heme degradation products (HHDPs) serve signaling roles important in physiology and pathophysiology. Our group is focused on microcirculation of the liver of mice. We will specifically investigate how heme oxygenase (HO) and HHDPs regulate hepatic stellate cells - the modulators of hepatic vascular tone - under naïve and stress conditions such as septic shock. Therefore our group established experimental systems for investigating the regulation of microcirculation by hepatic stellate cells in vitro (collagen-lattice-assay) and in vivo (intravital microscopy of the liver including a single organ perfusion system enabling direct visualization of stellate cells in their intact milieu). Functional consequences of altered perfusion are studied as changes in the redox state or excretory function of hepatocytes applying biophotonic strategies.
Prof. Bauer heads a group addressing molecular mechanisms and the prevention of organ failure in life-threatening infections. Key components of this research reflect strategies for early detection of pathogens and the ensuing immune response. Research thrusts include:
Prof. Bauer's teaching covers aspects of pathophysiology and molecular aspects in critical care medicine with a focus on life-threatening infections:
The laboratories led by Prof. Bauer offer a full range of molecular biology techniques with special emphasis of transcriptome/array analysis and in vivo microscopy of solid organs, including: