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BIOMIMETIC SIGNAL TRANSDUCTION

In our group we are currently working on two main topics:

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Nitric oxide (NO) and carbon monoxide (CO) are messenger molecules in the human body. NO- and CO-releasing materials (NORMAs & CORMAs) can act as gasotransmitter delivering devices in therapy; toxic metabolites after gas release are kept in the matrix. NO and CO photodonors use light as a trigger allowing the accurate control of site, timing and dosage. We work on the concept of embedding water-insoluble, photoactive and photosensitized NO and CO metal complexes into hybrid polymers, such as fibrous non-wovens and nanoparticles.

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Two-component saccharide sensing probes, based on anionic fluorescent dyes as reporters and boronic acid-appended bipyridinium salts as receptors, are used for high-throughput screening of novel carbohydrate enzymes and the detection of cyanides and fluorides in water. These probes can also perform Boolean logic operations to perform chemical computing with sugars.

Research areas

Prof. Schiller's research focuses on biomimetic signal transduction incorporating methods from the areas of materials- and bio-inorganic photo chemistry and supra-molecular analytical chemistry. Research thrusts include:

  • photo-inducible nitric oxide (NO) and carbon mon-
  • oxide (CO)-releasing molecules and materials
  • molecular probes for bioanalytes in water
  • molecular logic and computing using sensors and light

Teaching fields

Prof. Schiller's teaching activities involve inorganic chemistry courses for Bachelor's and Master's degree students, as well as student teachers. He holds lectures and gives courses in:

  • supramolecular inorganic chemistry
  • inorganic analytical chemistry
  • research skill development for scientists (www.schillermertens.de)

Research methods

Prof. Schiller's laboratories can perform advanced synthesis of small molecules and polymer materials. His research also includes chemometrics and basic programming techniques.The following analytical methods and equipment are available and utilized in these laboratories:

  • fluorescence and UV-Vis spectroscopy using a Varioskan plate reader (Thermo Fisher) and a Specord S 600 (Analytik Jena)
  • electrochemical detection of nitric oxide (NO) and carbon monoxide (CO)

>> link to the Biomimetic Signal Transduction Group

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