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BIOMOLECULAR PHOTONICS

Research areas

One of the aims of the Biomolecular Photonics Group is to establish new photonic techniques and to use them in biologic research. In conventional fluorescence microscopy only the information conferred by the fluorescence intensity is used to delineate microscopic structures or to perform quantitative measurements by the use of fluorescent indicator dyes. However, a fluorophore is not only characterized by the intensity of the emitted light, but also by its absorption and emission spectra, by its lifetime in the excited state and the polarization of the emitted light. This information can be exploited for functional imaging. Our methodological work focusses on:

  • multidimensional fluorescence lifetime imaging
  • optical protein-protein and protein-DNA interaction assays
  • structure-function relationships of ion channels
  • indicators and nanosensors for ions and biomolecules

Our biological interests includes tructural and functional relationships of ion channels and DNA-repair mechanisms.

Teaching fields

Prof. Biskup is in charge of the newly established course M.Sc. Medical Photonics which will start in winter term 2016. Moreover, he gives lectures and courses in:

  • physiology (for students of Pharmacy, Biochemistry/Molecular Biology, and Nutritional Science)
  • microscopic techniques (for students of Medicine, Molecular Medicine and Medical Photonics)
  • image processing

Research methods

The laboratories of the Biomolecular Photonics Group offer a wide range of methods used at the interface of physiology, physics and chemistry:

  • standard molecular biology techniques, cell culture
  • fluorescence and confocal laser scanning microscopy
  • fluorescence spectroscopy
  • spectrally resolved fluorescence lifetime measurements based on time-correlated single photon counting and streak camera measurements
  • patch-clamp fluorometry

>> link to the Biomolecular Photonics Group

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