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EXPERIMENTAL ANESTHESIOLOGY

Heme and heme degradation products (HHDPs) serve signaling roles important in physiology and pathophysiology. Our group is focused on microcirculation of the liver of mice. We will specifically investigate how heme oxygenase (HO) and HHDPs regulate hepatic stellate cells - the modulators of hepatic vascular tone - under naïve and stress conditions such as septic shock. Therefore our group established experimental systems for investigating the regulation of microcirculation by hepatic stellate cells in vitro (collagen-lattice-assay) and in vivo (intravital microscopy of the liver including a single organ perfusion system enabling direct visualization of stellate cells in their intact milieu). Functional consequences of altered perfusion are studied as changes in the redox state or excretory function of hepatocytes applying biophotonic strategies.

Research areas

Prof. Bauer heads a group addressing molecular mechanisms and the prevention of organ failure in life-threatening infections. Key components of this research reflect strategies for early detection of pathogens and the ensuing immune response. Research thrusts include:

  • culture-independent pathogen detection (in cooperation with Prof. Popp)
  • in vivo visualization of cellular redox state and function(s), such as dye uptake and excretion
  • in vivo and in situ monitoring of heme degradation plasmonics to describe the host response

Teaching fields

Prof. Bauer's teaching covers aspects of pathophysiology and molecular aspects in critical care medicine with a focus on life-threatening infections:

  • fundamentals of oxygen transport, energy metabolism and redox state
  • systems biology of sepsis and organ failure

Research methods

The laboratories led by Prof. Bauer offer a full range of molecular biology techniques with special emphasis of transcriptome/array analysis and in vivo microscopy of solid organs, including:

  • in vivo (fluorescence) microscopy to study cellular redox state, function and integrity
  • complementary application of Raman spectroscopy (in cooperation with Prof. Popp)

>> link to the Experimental Anesthesiology Group

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